Suranganie Dharmawardhane Selected Research

rho GTP-Binding Proteins (rho GTP-Binding Protein)

12/2021	Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer.
3/2021	Rho Family GTPases in Cancer.
10/2020	Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice.
1/2020	Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
1/2017	Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
2/2015	Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.
4/2012	Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
10/2010	Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.

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Suranganie Dharmawardhane Research Topics

Disease

23	Neoplasms (Cancer) 12/2021 - 01/2009
12	Neoplasm Metastasis (Metastasis) 12/2021 - 01/2009
10	Breast Neoplasms (Breast Cancer) 06/2021 - 01/2009
4	Body Weight (Weight, Body) 12/2021 - 10/2010
2	Inflammation (Inflammations) 01/2020 - 01/2018
1	Dysbiosis 01/2021
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2018
1	Obesity 01/2018
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2013
1	Systemic Mastocytosis 10/2013
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2013

Drug/Important Bio-Agent (IBA)

8	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 12/2021 - 10/2010
4	GTP Phosphohydrolases (GTPases)IBA 03/2021 - 10/2013
4	daidzeinIBA 01/2021 - 10/2010
4	IsoflavonesIBA 01/2021 - 10/2010
4	GenisteinIBA 01/2021 - 10/2010
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2012
4	Cell Surface ReceptorsIBA 01/2020 - 01/2013
3	p21-Activated KinasesIBA 12/2021 - 04/2012
3	Monomeric GTP-Binding ProteinsIBA 06/2021 - 01/2013
3	EquolIBA 01/2021 - 12/2012
3	glyciteinIBA 01/2021 - 10/2010
3	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 01/2020 - 04/2012
3	ResveratrolIBA 01/2016 - 01/2009
3	PolyphenolsIBA 01/2016 - 01/2009
3	Peptide Initiation Factors (Initiation Factor)IBA 03/2015 - 10/2010
2	CytokinesIBA 01/2020 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2020 - 01/2018
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2020 - 01/2018
2	Catechin (Z 7300)IBA 01/2016 - 01/2009
2	QuercetinIBA 01/2016 - 01/2009
2	Internal Ribosome Entry SitesIBA 03/2015 - 12/2012
2	Estrogen ReceptorsIBA 03/2015 - 01/2013
2	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)IBA 03/2015 - 12/2012
2	Green Fluorescent ProteinsIBA 10/2010 - 01/2009
1	Gefitinib (Iressa)FDA Link 06/2021
1	Lapatinib (GW572016)FDA Link 06/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Biological ProductsIBA 11/2020
1	Pharmaceutical PreparationsIBA 10/2020
1	Eicosapentaenoic AcidIBA 01/2020
1	IntegrinsIBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	Conditioned Culture MediaIBA 01/2020
1	Growth Factor ReceptorsIBA 01/2020
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2020
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2018
1	Botulinum Toxins (Botulinum Toxin)IBA 01/2017
1	cdc42 GTP-Binding ProteinIBA 01/2017
1	MicroRNAs (MicroRNA)IBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	Small Interfering RNA (siRNA)IBA 03/2015
1	Protein Isoforms (Isoforms)IBA 03/2015
1	Cadherins (E-Cadherin)IBA 02/2015
1	Cyclin D1IBA 02/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2015
1	Apoptosis Regulatory ProteinsIBA 02/2015
1	Cyclin DIBA 10/2014
1	Phosphotransferases (Kinase)IBA 10/2014
1	Caspase 3 (Caspase-3)IBA 10/2014
1	Codon (Codons)IBA 10/2013
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2013
1	ras ProteinsIBA 01/2013
1	NSC 23766IBA 01/2013
1	Eukaryotic Initiation Factor-4EIBA 12/2012
1	SurvivinIBA 10/2010
1	NF-kappa B (NF-kB)IBA 01/2009
1	NF-KappaB Inhibitor alphaIBA 01/2009
1	Estrogen Receptor alphaIBA 01/2009
1	Estrogen Receptor betaIBA 01/2009

Therapy/Procedure

6	Therapeutics 06/2021 - 10/2014
1	Oral Administration 12/2021